Presenting Mette Nyegaard who is professor in Genetics and Personalised Medicine and Head og Department of Congenital Disorders at Statens Serum Institute.

Mette’s research interest has for more than 20 years been on how changes in our DNA is linked to differences in our health and disease. A strong research focus has for the last 10 years been on endometriosis, identifying risk genes and translating this into mechanistic insight with a long term goal of identifying targets that can be used to slow down or possibly even cure endometriosis.

Mette and her team, in collaboration with the Danish Blood Donor study, has led the Danish contributed to a large international genome-wide association study, identifying 42 risk genes for endometriosis and identifying genetic overlap with other common complex traits such as pain perception.

Mette is leading the Danish part of of WP4. WP4 aims to identify molecular sub-types of endometriosis using genetics and to understand these subtypes by looking at differences in pain-profile, fertility, co-morbidities and biomarker profiles circulating in the blood.

A few selected publications:

1) Rahmioglu, N. et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 55, 423-436 (2023).

doi: 10.1038/s41588-023-01323-z

2) Kirstine Kloeve-Mogensen et al. Polygenic Risk Score Prediction for Endometriosis Frontiers,

doi: 10.3389/frph.2021.793226. eCollection 2021.